Gastric cancer is one of the malignant tumors with the highest incidence rate in the country, and ranks the third in cancer related deaths. At present, surgery is still the main means of curative treatment for gastric cancer, but 30% to 40% of patients with advanced gastric cancer lose the opportunity for curative surgery at the initial diagnosis. Therefore, transforming unresectable gastric cancer into resectable gastric cancer is the best choice for patients to achieve"cure". With the emergence of new drugs, the diversification of treatment methods, and the development of multidisciplinary diagnosis and treatment models in recent years, the concept of"translational therapy" has emerged, thereby extending the survival time of patients and improving their quality of life. This article provides a review of the current status and progress in the treatment of unresectable gastric cancer, as well as the application of transformation therapy.
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