Predictors of positive inotropic drug use in patients undergoing concomitant coronary artery bypass graft without cardiopulmonary bypass

Objective: To observe and analyze the factors related to the use of positive inotropic drugs in coronary artery bypass grafting(CABG) surgery. Method: A total of 630 patients(351 males and 279 females) who underwent off pump CABG at the Heart Center of Daxing District People's Hospital in Beijing from January 2012 to December 2013 were selected as the study subjects. According to whether positive inotropic drugs were used during surgery, they were divided into an applied group(n=330) and a non applied group(n=300). Collect clinical data by reviewing original medical records. The application of positive inotropic drugs is defined as the use of dopamine at doses exceeding 5 μg/(kg · min), any dose of adrenaline or norepinephrine, milrinone. Result: Three independent factors related to the application of positive inotropic drugs were identified:① Cardiac index(CI) ≤ 2.5 L/(min·m2); ② Left ventricular ejection fraction(LVEF) ≤ 35%; ③ Left ventricular end diastolic pressure(LVEDP) ≥ 25 mmHg. Conclusion: CI ≤ 2.5 L/(min · m2), LVEF ≤ 35%, and LVEDP ≥ 25 mmHg are independent related factors that increase the risk of using positive inotropic drugs in non extracorporeal circulation CABG.