Determination of solvent residues in biodegradable polyester, ethylene glycol, and propylene glycol copolymers

A method for the determination of residual solvents in glycolide propylene copolymer(PLGA) was established using a DB-624(30 m x 530 μ m x 3.0 μ m) capillary chromatography column, hydrogen flame ionization detector(FID), and headspace injection. The experimental results show that the peak area and mass concentration of each solvent measured by this method exhibit a good linear relationship within the investigated concentration range. The recovery rate is between 98.54% and 99.50%, the precision RSD is less than 2%, and the quantitative limit is between 0.16 and 1.17 μ g/mL. This method is simple to operate, accurate in results, and has good reproducibility. It can be used for the simultaneous determination of residual solvents such as ethanol, acetone, dichloromethane, and ethyl acetate in PLGA.